Cefuroxime 250 Mg Side Effects in Nursing Baby

Cefuroxime

Clinical data
Trade names	Zinacef, Ceftin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601206
License data	US  DailyMed:Cefuroxime
Pregnancy category	B
Routes of administration	Intramuscular, intravenous, past rima oris
Drug class	Second-generation cephalosporin
ATC code	J01DC02 (WHO) S01AA27 (WHO) QJ51DC02 (WHO)
Legal status
Legal status	AU: S4 (Prescription merely) In general: ℞ (Prescription but)
Pharmacokinetic data
Bioavailability	37% on an empty stomach, upwards to 52% if taken after food
Elimination half-life	80 minutes
Excretion	Urine 66–100% unchanged
Identifiers
IUPAC name (6R,sevenR)-3-{[(Aminocarbonyl)oxy]methyl}-seven-{[(2Z)-2-(2-furyl)-two-(methoxyimino)acetyl]amino}-8-oxo-v-thia-1-azabicyclo[four.ii.0]oct-2-ene-2-carboxylic acid
CAS Number	55268-75-ii Y
PubChem CID	5361202
DrugBank	DB01112 Y
ChemSpider	4514699 Y
UNII	O1R9FJ93ED
KEGG	D00262 Y
ChEMBL	ChEMBL466 Y
CompTox Dashboard (EPA)	DTXSID5022774
ECHA InfoCard	100.054.127
Chemical and physical data
Formula	C 16 H 16 N 4 O eight Southward
Molar mass	424.38 k·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)\c3occc3)COC(=O)N)C(=O)O
InChI InChI=1S/C16H16N4O8S/c1-26-19-nine(8-iii-2-four-27-8)12(21)18-10-13(22)20-eleven(15(23)24)7(5-28-16(17)25)6-29-14(ten)xx/h2-4,ten,14H,five-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9+/t10-,xiv-/m1/s1 Y Key:JFPVXVDWJQMJEE-SWWZKJRFSA-N Y
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Cefuroxime, sold under the brand proper noun Zinacef among others, is a 2nd-generation cephalosporin^[i] antibody used to treat and prevent a number of bacterial infections.^[2] These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme affliction.^[three] Information technology is used by mouth or by injection into a vein or muscle.^[3]

Common side furnishings include nausea, diarrhea, allergic reactions, and pain at the site of injection.^[3] Serious side furnishings may include Clostridium difficile infection, anaphylaxis, and Stevens–Johnson syndrome.^[three] Apply in pregnancy and breastfeeding is believed to be condom.^[4] It is a second-generation cephalosporin and works past interfering with a bacteria's ability to make a prison cell wall resulting in its death.^[3]

Cefuroxime was patented in 1971, and approved for medical use in 1977.^[5] It is on the World Health Organization's List of Essential Medicines.^[6] In 2017, it was the 342nd most commonly prescribed medication in the United states, with more than 800 g prescriptions.^[7]

Medical uses [edit]

Cefuroxime is agile against many leaner including susceptible strains of Staphylococci and Streptococci, equally well as a range of gram negative organisms.^[viii] Every bit with the other cephalosporins, it is susceptible to beta-lactamase, although as a second-generation variety, it is less so. Hence, information technology may have greater activeness confronting Haemophilus influenzae, Neisseria gonorrhoeae, and Lyme disease. Unlike other second-generation cephalosporins, cefuroxime can cross the blood-brain bulwark.^[9]

A systematic review institute high quality show that injecting the eye with cefuroxime afterward cataract surgery will lower the chance of developing endophthalmitis afterward surgery.^[10]

Side effects [edit]

Cefuroxime is more often than not well tolerated, and its side effects are usually transient. If ingested afterward food, this antibody is both meliorate absorbed and less likely to crusade its well-nigh common side effects of diarrhea, nausea, vomiting, headaches/migraines, dizziness, and abdominal hurting compared to most antibiotics in its class.^{[ medical citation needed ]}

Although a widely stated cross-allergic risk of about 10% exists betwixt cephalosporins and penicillin, recent^{[ when? ]} assessments have shown no increased hazard for a cross-allergic reaction for cefuroxime and several other 2d-generation or later cephalosporins.^[11]

Chemistry [edit]

Cefuroxime axetil is an acetoxyethyl ester prodrug of cefuroxime which is constructive when taken past mouth.^[12] It is a 2nd-generation cephalosporin.

Trade names [edit]

In the U.Southward. it is marketed as Zinacef by Covis Pharmaceuticals since the company acquired the U.Due south. rights to the product from GSK.^[xiii] GSK had continued marketing a pediatric oral intermission every bit Ceftin; however, this presentation was discontinued as of 24 June 2017.^[14]

In Bangladesh, it is available as Axim past Aristopharma, Rofurox by Radiant, Kilbac by Incepta and Xorimax by Sandoz. In India, it is available as Ceftum in tablet course and Supacef in injection class by GSK.^[xv] In Poland, it is available equally Zamur by Mepha, subsidiary of Teva Pharmaceutical Industries.^[16] In Australia, the "first generic" form of Cefuroxime axetil, Pharmacor Cefuroxime (tablets) from Pharmacor Pty Ltd, was registered on 27 March 2017, past the Therapeutic Goods Assistants.^[17] Cefuroxime axetil is likewise available (in two strengths) every bit granules for oral suspension from Aspen Pharmacare Australia Pty Ltd under the brand name Zinnat cefuroxime.^[eighteen]

References [edit]

1. ^ Katzung, Bertram (2018). Bones & Clinical Pharmacology. McGraw Colina. p. 803.
2. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 518. ISBN9780857113382.
3. ^ ^{a b c d e} "Cefuroxime Sodium Monograph for Professionals". Drugs.com. American Gild of Health-System Pharmacists. Retrieved 22 March 2019.
4. ^ "Cefuroxime Use During Pregnancy". Drugs.com . Retrieved 3 March 2019.
5. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 493. ISBN9783527607495.
6. ^ Earth Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: Globe Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC By-NC-SA 3.0 IGO.
7. ^ "Cefuroxime – Drug Usage Statistics". ClinCalc . Retrieved xi April 2020.
8. ^ "Appendix 5 – Antibiotic overview". Wellington ICU Drug Manual . Retrieved 10 December 2020.
9. ^ Root, Richard K.; Waldvogel, Francis; Corey, Lawrence; Stamm, Walter E. (1999). Clinical Infectious Diseases: A Practical Arroyo. Oxford University Press. p. 259. ISBN9780195081039.
10. ^ Gower EW, Lindsley Thou, Tulenko SE, Nanji AA, Leyngold I, McDonnell PJ (2017). "Perioperative antibiotics for prevention of acute endophthalmitis subsequently cataract surgery". Cochrane Database Syst Rev. 2: CD006364. doi:10.1002/14651858.CD006364.pub3. PMC5375161. PMID 28192644.
11. ^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of Family Do. 55 (2): 106–12. PMID 16451776. Archived from the original (PDF) on 24 February 2012.
12. ^ Walter Sneader (23 June 2005). Drug Discovery: History. ISBN9780471899792.
13. ^ http://www.covispharma.ch/avails/pdf/covis-pharma-acquires-portfolio-of-drugs-from-glaxosmithkline.pdf ^{[ dead link ]}
14. ^ "FDA Drug Shortages". Food and Drug Administration (FDA). twenty March 2018.
15. ^ "GlaxoSmithKline Pharmaceuticals Limited – Prescription Medicines – Anti-Infective". Gsk-bharat.com. 26 March 2013.
16. ^ "Charakterystyka produktu lecznicznego" (PDF). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych. 12 November 2015.
17. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". TGA. Therapeutic Appurtenances Administration. 26 March 2018. Retrieved 30 July 2018.
18. ^ "ARTG ID 81301". TGA. Therapeutic Goods Assistants. Retrieved 30 July 2018.

External links [edit]

• "Cefuroxime". Drug Information Portal. U.S. National Library of Medicine.

Cefuroxime 250 Mg Side Effects in Nursing Baby

Source: https://en.wikipedia.org/wiki/Cefuroxime